abstract：:Human papillomavirus (HPV) infection is associated with several cancers such as cancer in the cervix, vagina, and vulva and oropharyngeal, anal, penile, and cutaneous carcinomas, which is regarded as a great public health concern. The association between HPV is the strongest with cervical cancer because almost all suc...

journal_title：Advances in experimental medicine and biology

authors： Li Y,Xu C

更新日期：2017-01-01 00:00:00

abstract：:Small activating RNA (saRNA)-mediated gene activation has opened a new avenue for upregulating the expression of target genes by promoting endogenous transcription, a phenomenon known as RNA activation (RNAa). RNAa is distinct from the established RNAi mechanistic framework, although AGO2 is required by both. The prec...

journal_title：Advances in experimental medicine and biology

authors： Cao H,Meng X,Wang X,Liang Z

更新日期：2017-01-01 00:00:00

abstract：:TRPC channels have been suggested as potential candidates mediating store-operated Ca2+ entry (SOCE) in cardiomyocytes. There is increasing evidence that the TRPC isoforms TRPC1 and TRPC4 might fulfill the function as SOCs, in concert with or in parallel to the key players of SOCE, Orai1, and STIM1. Several other isof...

journal_title：Advances in experimental medicine and biology

authors： Eder P

更新日期：2017-01-01 00:00:00

abstract：:Store-operated Ca2+ entry (SOCE) is a cell signaling pathway essential for immune and muscle function controlled by dynamic interactions between Ca2+-sensing STIM proteins on the endoplasmic reticulum (ER) and Ca2+-permeable ORAI channels on the plasma membrane (PM). STIM-ORAI interactions occur at membrane contact si...

journal_title：Advances in experimental medicine and biology

authors： Demaurex N,Guido D

更新日期：2017-01-01 00:00:00

abstract：:Store-operated Ca2+ entry fulfills a crucial role in controlling Ca2+ signals in almost all cells. The Ca2+-sensing stromal interaction molecule (STIM) proteins in the endoplasmic reticulum (ER) undergo complex conformational changes in response to depleted ER luminal Ca2+, allowing them to unfold and become trapped i...

journal_title：Advances in experimental medicine and biology

authors： Nwokonko RM,Cai X,Loktionova NA,Wang Y,Zhou Y,Gill DL

更新日期：2017-01-01 00:00:00

abstract：:Diseases can be caused naturally by biological agents such as bacteria, viruses and toxins (natural risk). However, such biological agents can be intentionally disseminated in the environment by a State (military context) or terrorists to cause diseases in a population or livestock, to destabilize a nation by creating...

journal_title：Advances in experimental medicine and biology

authors： Avril A

更新日期：2017-01-01 00:00:00

abstract：:The use of small animal models for the study of infectious disease is critical for understanding disease progression and for developing prophylactic and therapeutic treatment options. For many diseases, Syrian golden hamsters have emerged as an ideal animal model due to their low cost, small size, ease of handling, an...

journal_title：Advances in experimental medicine and biology

authors： Warner BM,Safronetz D,Kobinger GP

更新日期：2017-01-01 00:00:00

abstract：:Stimulator of interferon (IFN) genes (STING) is a key mediator in the immune response to cytoplasmic DNA sensed by cyclic GMP-AMP (cGAMP) synthase (cGAS). After synthesis by cGAS, cGAMP acts as a second messenger activating STING in the cell harboring cytoplasmic DNA but also in adjacent cells through gap junction tra...

journal_title：Advances in experimental medicine and biology

authors： Pépin G,Gantier MP

更新日期：2017-01-01 00:00:00

abstract：:A monodispersed and ideal solution is a central (unique?) requirement of SAXS to allow one to extract structural information from the recorded pattern. On-line Size Exclusion Chromatography (SEC) marked a major breakthrough, separating particles present in solution according to their size. Identical frames under an el...

journal_title：Advances in experimental medicine and biology

authors： Pérez J,Vachette P

更新日期：2017-01-01 00:00:00

abstract：:Susceptibility to type 1 diabetes (T1D) is determined by interactions of multiple genes with environmental triggers. Thus far, more than 50 T1D susceptibility regions have been suggested from genetic studies by employing either genome-wide or candidate gene approaches. Because the lack of a linear correlation between ...

journal_title：Advances in experimental medicine and biology

authors： Zhang J,Chen Z,Zhou Z,Yang P,Wang CY

更新日期：2017-01-01 00:00:00

abstract：:Small angle scattering (SAS) is a powerful and versatile tool to elucidate the structure of matter at the nanometer scale. Recently, the technique has seen a tremendous growth of applications in the field of structural molecular biology. Its origins however date back to almost a century ago and even though the methods...

journal_title：Advances in experimental medicine and biology

authors： Weiss TM

更新日期：2017-01-01 00:00:00

abstract：:Recently, a role for SUMO modification outside of the nucleus has emerged. Although the number of extranuclear proteins known to be sumoylated is comparatively small, ion channels represent one important new class of these proteins. Ion channels are responsible for the control of membrane excitability and therefore ar...

journal_title：Advances in experimental medicine and biology

authors： Benson M,Iñiguez-Lluhí JA,Martens J

更新日期：2017-01-01 00:00:00

abstract：:Chemometrics has been a fundamental discipline for the development of metabolomics, while symbiotically growing with it. From design of experiments, through data processing, to data analysis, chemometrics tools are used to design, process, visualize, explore and analyse metabolomics data.In this chapter, the most comm...

journal_title：Advances in experimental medicine and biology

authors： Pinto RC

更新日期：2017-01-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a deadly and increasingly prevalent vascular disease characterized by excessive pulmonary vascular remodeling and right ventricular dysfunction which leads to right heart failure, multiorgan dysfunction, and premature death. The cause of the vascular remodeling in PH remains elusive, and...

journal_title：Advances in experimental medicine and biology

authors： Yu Q,Chan SY

更新日期：2017-01-01 00:00:00

abstract：:Pulmonary hypertension is a complex disease of the pulmonary vasculature, which in severe cases terminates in right heart failure. Complex remodeling of pulmonary arteries comprises the central issue of its pathology. This includes extensive proliferation, apoptotic resistance and inflammation. As such, the molecular ...

journal_title：Advances in experimental medicine and biology

authors： Plecitá-Hlavatá L,D'alessandro A,El Kasmi K,Li M,Zhang H,Ježek P,Stenmark KR

更新日期：2017-01-01 00:00:00

abstract：:Drug resistance is best thought of as an ongoing biological process. Resistant bacteria must emerge, become established and ultimately transmit in order to be relevant to human health. In this context, genetic diversity can influence the rate and likelihood of resistance emerging; it can also modulate the net physiolo...

journal_title：Advances in experimental medicine and biology

authors： Borrell S,Trauner A

更新日期：2017-01-01 00:00:00

abstract：:Redox signaling plays a critical role in the pathophysiology of cardiovascular diseases. The pentose phosphate pathway is a major source of NADPH redox in the cell. The activities of glucose-6-phosphate dehydrogenase (the rate-limiting enzyme in the pentose shunt) and glucose flux through the shunt pathway is increase...

journal_title：Advances in experimental medicine and biology

authors： Hashimoto R,Gupte S

更新日期：2017-01-01 00:00:00

abstract：:Conservatively, ten million people in the USA alone may suffer from RH and may be similarly prevalent elsewhere. Given the strong linear correlation between hypertension and cardiovascular outcomes, better control is paramount. We favor a multi-pronged approach. It may not suffice to address this by pharmacologic mean...

journal_title：Advances in experimental medicine and biology

authors： Valsan D,Burhan U,Teehan G

更新日期：2017-01-01 00:00:00

abstract：:The application of next generation sequencing technologies has opened the door to a new molecular epidemiology of tuberculosis, in which we can now look at transmission at a resolution not possible before. At the same time, new technical and analytical challenges have appeared, and we are still exploring the wider pot...

journal_title：Advances in experimental medicine and biology

authors： Comas I

更新日期：2017-01-01 00:00:00

abstract：:Sarcopenia is recognized as a major health problem among older adults. This syndrome is associated with serious health consequences in terms of frailty, disability, morbidity and mortality. The aim of this study is to review sarcopenia and its impact on quality of life (QoL). MEDLINE database was searched from January...

journal_title：Advances in experimental medicine and biology

authors： Tsekoura M,Kastrinis A,Katsoulaki M,Billis E,Gliatis J

更新日期：2017-01-01 00:00:00

abstract：:Psychological therapies in order to provide cognitive enhancement have gained some momentum the last decades. The goal of this case study was to evaluate the effects of a cognitive enhancement training program on daily living activities, cognition, and depression in a demented elderly participant. A 6-month training p...

journal_title：Advances in experimental medicine and biology

authors： Stratakou GD,Plerou A

更新日期：2017-01-01 00:00:00

abstract：:Programmatic assessment is being adopted as a preferred method of assessment in postgraduate medical education in Australia. Programmatic assessment of professionalism is likely to receive increasing attention. This paper reviews the literature regarding the assessment of professionalism in psychiatry. A search using ...

journal_title：Advances in experimental medicine and biology

authors： Plakiotis C

更新日期：2017-01-01 00:00:00

abstract：:The impulse oscillometry (IOS) is recognized as a complementary method to spirometry in the diagnostics of obstructive pulmonary disorders. The IOS enables to measure total respiratory resistance (R5) and proximal respiratory resistance (R20), with the R5-R20 difference reflecting small airway resistance. This study s...

journal_title：Advances in experimental medicine and biology

authors： Piorunek T,Kostrzewska M,Stelmach-Mardas M,Mardas M,Michalak S,Goździk-Spychalska J,Batura-Gabryel H

更新日期：2017-01-01 00:00:00

abstract：:Electrical Impedance Tomography (EIT) is a promising application that displays changes in conductivity within a body. The basic principle of the method is the repeated measurement of surface voltages of a body, which are a result of rolling injection of known and small-volume sinusoidal AC current to the body through ...

journal_title：Advances in experimental medicine and biology

authors： Lymperopoulos G,Lymperopoulos P,Alikari V,Dafogianni C,Zyga S,Margari N

更新日期：2017-01-01 00:00:00

abstract：:Although significant advances have been made in understanding several cognitive states, the algorithmic thinking ability is yet to be analyzed in terms of neuroscience and brain imaging techniques. Studies on the effects of neurofeedback on learning disabilities especially mathematics disorders are limited. The object...

journal_title：Advances in experimental medicine and biology

authors： Plerou A,Vlamos P,Margetaki A

更新日期：2017-01-01 00:00:00

abstract：:A community is an important attribute of networking, since people who join networks tend to join communities. Community detection is used to identify and understand the structure and organization of real-world networks, thus, it has become a problem of considerable interest. The study of communities is highly related ...

journal_title：Advances in experimental medicine and biology

authors： Souravlas SI,Sifaleras A

更新日期：2017-01-01 00:00:00

abstract：:In this chapter, we intend to review gene therapy concepts applied to the potential treatment of tyrosinemia for parents and pediatricians. Therefore, our main objective is to give general informations in a comprehensible manner. Considering the nature of tyrosinemia and the current state of technology, a particular f...

journal_title：Advances in experimental medicine and biology

authors： Carter S,Doyon Y

更新日期：2017-01-01 00:00:00

abstract：:Assessment is a key element in education. Given its multiple methods, assessment contains the aspect of correctness and honesty from both the assessor and the assessed. These methods can be classified and their types are numerous, starting from single questions to tests and practical work. Concerning tests, their vast...

journal_title：Advances in experimental medicine and biology

authors： Popescu DA,Nijloveanu D,Bold N

更新日期：2017-01-01 00:00:00

abstract：:Hepatorenal tyrosinaemia (HT1) is a serious condition that used to be fatal before the advent of nitisinone (NTBC, Orfadine®) as a therapeutic option. We have recently shown that selective screening is inadequate as initial symptoms are often uncharacteristic which leads to a considerable delay in diagnosis and treatm...

journal_title：Advances in experimental medicine and biology

authors： Das AM,Mayorandan S,Janzen N

更新日期：2017-01-01 00:00:00

abstract：:Given the interest of many people and families directly or indirectly affected by hereditary tyrosinemia (HT1), I have tried to give my view on the history of the disease from 1965 to 2015 (Fig. 1.1). ...

journal_title：Advances in experimental medicine and biology

authors： Larochelle J

更新日期：2017-01-01 00:00:00

abstract：:Despite the enormous efforts of the scientific community over the years, effective therapeutics for many (epi)genetic brain disorders remain unidentified. The common and persistent failures to translate preclinical findings into clinical success are partially attributed to the limited efficiency of current disease mod...

journal_title：Advances in experimental medicine and biology

authors： Riemens RJM,Soares ES,Esteller M,Delgado-Morales R

更新日期：2017-01-01 00:00:00

abstract：:Schizophrenia is a complex neuropsychiatric disorder with high heritability; however, family and twin studies have indicated that environmental factors also play important roles in the etiology of disease. Environmental triggers exert their influence on behavior via epigenetic mechanisms. Epigenetic modifications, suc...

journal_title：Advances in experimental medicine and biology

authors： Thomas EA

更新日期：2017-01-01 00:00:00

abstract：:Rubinstein-Taybi syndrome (RSTS) is a rare genetic disorder in humans characterized by growth and psychomotor delay, abnormal gross anatomy, and mild to severe mental retardation (Rubinstein and Taybi, Am J Dis Child 105:588-608, 1963, Hennekam et al., Am J Med Genet Suppl 6:56-64, 1990). RSTS is caused by de novo mut...

journal_title：Advances in experimental medicine and biology

authors： Korzus E

更新日期：2017-01-01 00:00:00

abstract：:Tumor exists as a complex network of structures with an ability to evolve and evade the host immune surveillance mechanism. The immune milieu which includes macrophages, dendritic cells, natural killer cells, neutrophils, mast cells, B cells, and T cells are found in the core, the invasive margin, or the adjacent stro...

journal_title：Advances in experimental medicine and biology

authors： Stephen B,Hajjar J

更新日期：2017-01-01 00:00:00

abstract：:One of the key players in both hemostasis and thrombosis is von Willebrand factor (vWF), which demonstrates a duality between these two processes. Thrombus is structured by numerous elements, including endothelial cells, platelets, plasma proteins and shear stress alteration. In circulation, once a vessel wall is inju...

journal_title：Advances in experimental medicine and biology

authors： Shahidi M

更新日期：2017-01-01 00:00:00

abstract：:An increasing body of evidence suggests the likelihood of a link between venous and arterial thrombosis. The two vascular complications share several risk factors, such as age, obesity, smoking, diabetes mellitus, blood hypertension, hypertriglyceridemia, and metabolic syndrome. Moreover, there are many examples of co...

journal_title：Advances in experimental medicine and biology

authors： Prandoni P

更新日期：2017-01-01 00:00:00

abstract：:The processes of bone growth and turnover are tightly regulated by the actions of various signaling molecules, including hormones, growth factors, and cytokines. Imbalances in these processes can lead to skeletal disorders such as osteoporosis or high bone mass disease. It is becoming increasingly clear that serotonin...

journal_title：Advances in experimental medicine and biology

authors： Lavoie B,Lian JB,Mawe GM

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells that reside in various organs. They have the capacity to differentiate into various cell types, including cardiomyocytes, vascular endothelial cells, and vascular smooth muscle cells. Among the various MSCs, bone marrow-derived MSCs (BMMSCs) have been widely use...

journal_title：Advances in experimental medicine and biology

authors： Suzuki E,Fujita D,Takahashi M,Oba S,Nishimatsu H

更新日期：2017-01-01 00:00:00

abstract：:Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME,...

journal_title：Advances in experimental medicine and biology

authors： Li Y,Wan YY,Zhu B

更新日期：2017-01-01 00:00:00

abstract：:Cell-cell communication is crucial to maintain homeostasis in multicellular organism. Cells communicate each other by direct contact or by releasing factors that, soluble or packaged in membrane vesicles, can reach different regions of the organism. To date numerous studies highlighted the existence of several types o...

journal_title：Advances in experimental medicine and biology

authors： Conigliaro A,Fontana S,Raimondo S,Alessandro R

更新日期：2017-01-01 00:00:00